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When this particular enzyme is reduced, the body stops the degradation of a substance called cyclic Guanosine Monophosphate cGMP. Retrieved 21 November Hindustan Times.

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It is typically referred to as a vascular disease. Improbable Research.

Drug Discovery. Nitric oxide NO in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation vasodilation of the intimal cushions of the helicine arteries. Cochrane Database of Systematic Reviews.